AQA A-Level Biology: Using Genome Projects (8.3) Lesson

This fully-resourced lesson guides teachers through the use of genome sequencing in simple and complex organisms. Designed to cover point 8.3 of the AQA A-level Biology specification, it connects key concepts across the syllabus to deepen student understanding.

Key Features:

• Introduction to Sanger’s Method:

  • Step-by-step explanation of the chain termination method, including the role of modified nucleotides and radioactive labeling.
  • Links to prior knowledge of DNA replication and protein synthesis (topics 2 and 4).
  • Overview of gel electrophoresis, preparing students for further exploration in topic 8.4.3.

• Applications of Sequencing:

  • Focus on simple organisms like viruses and bacteria, linking to bacterial pathogenesis.
  • Real-world relevance through examples and challenges via exam-style questions.

• Advancements and Challenges:

  • Explores difficulties in translating genome data into proteome knowledge.
  • Discusses the development and importance of automated methods for genome sequencing.

This lesson integrates foundational knowledge with advanced concepts, preparing students to understand genome sequencing’s processes and applications in both research and real-world contexts.

• Exam Board: AQA
• Subject: Biology
• Level: A-Level
• Resource Type: Lesson
• Year: 2025
• Year Group/s: Year 12 and Year 13

This resource was created by GJHeducation